Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Diaph1tm1.1Sna
Name:	diaphanous related formin 1; targeted mutation 1.1, Shuh Narumiya
MGI ID:	MGI:3761497
Synonyms:	mDia1-
Gene:	Diaph1  Location: Chr18:37976654-38068529 bp, - strand  Genetic Position: Chr18, 19.71 cM
Alliance:	Diaph1tm1.1Sna page

Germline Transmission:	Earliest citation of germline transmission: J:126090
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1 and a neo cassette flanked by frt sites and containing a 3' loxP site was inserted downstream of exon 1. The neo cassette and exon 1 was removed by cre-mediated recombination following a cross to Tg(EIIa-cre)C5379Lmgd mice. Insertion and removal of the neo cassette and exon 1 was confirmed by PCR analysis on genomic DNA. Absence of protein was confirmed by western blot analysis on brain, lung and thymus homogenate. (J:126090)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Diaph1 Mutation:	116 strains or lines available

Original:	J:126090 Sakata D, et al., Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J Exp Med. 2007 Sep 3;204(9):2031-8
All:	7 reference(s)