Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdk4tm2.1Bbd
Name:	cyclin dependent kinase 4; targeted mutation 2.1, Mariano Barbacid
MGI ID:	MGI:3759558
Synonyms:	Cdk4-
Gene:	Cdk4  Location: Chr10:126899404-126903157 bp, + strand  Genetic Position: Chr10, 74.5 cM, cytoband D3
Alliance:	Cdk4tm2.1Bbd page

Germline Transmission:	Earliest citation of germline transmission: J:125217
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 2 through 4 and a loxP-flanked selection cassette were removed by Flpe-mediated recombination. Removal of the exons was confirmed by Southern blot. (J:125217)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdk4 Mutation:	57 strains or lines available

Original:	J:125217 Barriere C, et al., Mice thrive without Cdk4 and Cdk2. Mol Oncol. 2007 Jun;1(1):72-83
All:	4 reference(s)