Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Robo2tm1.1Rilm
Name:	roundabout guidance receptor 2; targeted mutation 1.1, Richard Maas
MGI ID:	MGI:3759448
Synonyms:	Robo2del5
Gene:	Robo2  Location: Chr16:73688727-74208713 bp, - strand  Genetic Position: Chr16, 42.17 cM
Alliance:	Robo2tm1.1Rilm page

Germline Transmission:	Earliest citation of germline transmission: J:125214
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 5 was removed by cre-mediated recombination. A marked reduction in transcript size and quantity was confirmed by RT-PCR and in situ hybridization. Authors state that this allele is a null allele. (J:125214)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Robo2 Mutation:	101 strains or lines available

Original:	J:125214 Lu W, et al., Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet. 2007 Apr;80(4):616-32
All:	14 reference(s)