Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nlgn3tm2.1Sud
Name:	neuroligin 3; targeted mutation 2.1, Thomas C Sudhof
MGI ID:	MGI:3758960
Gene:	Nlgn3  Location: ChrX:100342785-100364956 bp, + strand  Genetic Position: ChrX, 43.95 cM
Alliance:	Nlgn3tm2.1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:125344
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 2 and 3 were removed by cre-mediated recombination that also removed the neo cassette. The loss of protein expression was confirmed by western blot analysis using two antibodies (528B and 639B). (J:125344)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nlgn3 Mutation:	35 strains or lines available

Original:	J:125344 Tabuchi K, et al., A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science. 2007 Oct 5;318(5847):71-6
All:	7 reference(s)