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Kcnk9tm1Wwis
Targeted Allele Detail
Summary
Symbol: Kcnk9tm1Wwis
Name: potassium channel, subfamily K, member 9; targeted mutation 1, W Wisden
MGI ID: MGI:3757590
Synonyms: Kcnk9tm1Sgb, TASK3-KO
Gene: Kcnk9  Location: Chr15:72372938-72418189 bp, - strand  Genetic Position: Chr15, 33.46 cM
Alliance: Kcnk9tm1Wwis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124944
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details4 copies of a selection cassette containing a loxP flanked exon 1 and a frt flanked neomycin resistance gene inserted in tandem into exon 1. In situ hybridization on brains of homozygotes indicated that the multiple repeats disrupted gene expression. Expression of adjacent genes was not affected as determined by in situ hybridization. (J:124944)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnk9 Mutation:  16 strains or lines available
References
Original:  J:124944 Brickley SG, et al., TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons. J Neurosci. 2007 Aug 29;27(35):9329-40
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory