Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mrc2tm1Cmi
Name:	mannose receptor, C type 2; targeted mutation 1, Clare M Isacke
MGI ID:	MGI:3722867
Synonyms:	Endo180deltaEx2-6, Endo180deltaEx2-6
Gene:	Mrc2  Location: Chr11:105183469-105241965 bp, + strand  Genetic Position: Chr11, 68.73 cM, cytoband E1
Alliance:	Mrc2tm1Cmi page

Germline Transmission:	Earliest citation of germline transmission: J:124909
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: A targeting vector was designed to replace exons 2-5 and part of exon 6 with a neomycin resistance cassette. Analysis of mutant MEFs determined that a transcript is produced, and sequencing showed it resulted from exon 1 being spliced to exon 7, with a continuous open reading frame. A protein lacking the cysteine-rich domain (exon 2), the FNII domain (exon 3) and the first CTLD (exons 4-6) was expressed. (J:124909)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Mrc2 Mutation:	119 strains or lines available

Original:	J:124909 East L, et al., A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep. 2003 Jul;4(7):710-6
All:	4 reference(s)