Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nlrc4tm1Gln
Name:	NLR family, CARD domain containing 4; targeted mutation 1, Jorge E Galan
MGI ID:	MGI:3722152
Synonyms:	ipaf-
Gene:	Nlrc4  Location: Chr17:74733254-74766140 bp, - strand  Genetic Position: Chr17, 45.64 cM
Alliance:	Nlrc4tm1Gln page

Germline Transmission:	Earliest citation of germline transmission: J:124378
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector inserted the IRES/nls-lacZ/MC1neo cassette to replace exons 2 and 3. RT-PCR confirmed absence of transcript in mutants. (J:124378)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrc4 Mutation:	67 strains or lines available

Original:	J:124378 Lara-Tejero M, et al., Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med. 2006 Jun 12;203(6):1407-12
All:	38 reference(s)