Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Foxo3tm1Nmt
Name:	forkhead box O3; targeted mutation 1, Noboru Motoyama
MGI ID:	MGI:3719789
Synonyms:	Foxo3a-
Gene:	Foxo3  Location: Chr10:42057841-42152691 bp, - strand  Genetic Position: Chr10, 22.79 cM
Alliance:	Foxo3tm1Nmt page

Germline Transmission:	Earliest citation of germline transmission: J:123409
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exon 2 was replaced with a neo cassette. (J:142870)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Foxo3tm1Nmt

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxo3 Mutation:	48 strains or lines available

Original:	J:123409 Huntington ND, et al., Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol. 2007 Aug;8(8):856-863
All:	16 reference(s)