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Erftm1Gmav
Targeted Allele Detail
Summary
Symbol: Erftm1Gmav
Name: Ets2 repressor factor; targeted mutation 1, George Mavrothalassitis
MGI ID: MGI:3719472
Synonyms: Erf-, Erfdl1, ErfKO
Gene: Erf  Location: Chr7:24941986-24950186 bp, - strand  Genetic Position: Chr7, 13.73 cM
Alliance: Erftm1Gmav page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123628
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector replaced exons 2, 3 and part of exon 4, sequences that encode the DNA binding domain, with a floxed neomycin resistance cassette. Expression of a cre transgene carried by the parental ES cells removed the floxed neo cassette upon passage through the male germline. Northern blot confirmed absence of transcript in mutant mice. (J:123628)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erf Mutation:  31 strains or lines available
References
Original:  J:123628 Papadaki C, et al., Transcriptional repressor erf determines extraembryonic ectoderm differentiation. Mol Cell Biol. 2007 Jul;27(14):5201-13
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory