Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hdac2tm1.2Eno
Name:	histone deacetylase 2; targeted mutation 1.2, Eric N Olson
MGI ID:	MGI:3717930
Synonyms:	Hdac2-
Gene:	Hdac2  Location: Chr10:36850540-36877885 bp, + strand  Genetic Position: Chr10, 19.44 cM, cytoband B1
Alliance:	Hdac2tm1.2Eno page

Germline Transmission:	Earliest citation of germline transmission: J:123173
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/SvEv

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 2-4 were removed via cre mediated recombination. RT-PCR detected a complete absence of mRNA encoding exons 2-4, but the presence of alternatively spliced transcripts downstream of the deletion. Protein expression was not detected from these transcripts. (J:123173)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac2 Mutation:	38 strains or lines available

Original:	J:123173 Montgomery RL, et al., Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 2007 Jul 15;21(14):1790-802
All:	5 reference(s)