Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Hsd3b7tm1Rus Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; targeted mutation 1 David W Russell MGI ID: MGI:3716711 Synonyms: Hsd3b7- Gene: Hsd3b7  Location: Chr7:127399830-127402975 bp, + strand  Genetic Position: Chr7, 69.74 cM Alliance: Hsd3b7tm1Rus page

Phenotypes of Hsd3b7tm1Rus/Hsd3b7tm1Rus mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:122973
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-6 were replaced by the ACN cassette encoding neomycin resistance and cre recombinase. Passage through the germline resulted in the deletion of the cassette, leaving a single loxP site. Protein was not detected in immunoblot of mutants. (J:122973)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hsd3b7 Mutation:	18 strains or lines available

Original:	J:122973 Shea HC, et al., Inaugural Article: Analysis of HSD3B7 knockout mice reveals that a 3{alpha}-hydroxyl stereochemistry is required for bile acid function. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11526-33
All:	4 reference(s)