Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Dntttm1Fwa
Name:	deoxynucleotidyltransferase, terminal; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:3715912
Synonyms:	TdT-
Gene:	Dntt  Location: Chr19:41017714-41047964 bp, + strand  Genetic Position: Chr19, 34.32 cM
Alliance:	Dntttm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:75921
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting vector was used to eliminate the Dntt promoter and exon 1 by homologous recombination. Terminal deoxynucleotidyl transferase enzymatic activity or transcripts from the mutant allele are not detected in Dntt-null thymocytes by RNA blotting. (J:75921)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dntt Mutation:	34 strains or lines available

Original:	J:75921 Komori T, et al., Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science. 1993 Aug 27;261(5125):1171-5
All:	1 reference(s)