Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itga11tm1Dgul
Name:	integrin alpha 11; targeted mutation 1, Donald Gullberg
MGI ID:	MGI:3714472
Synonyms:	alpha11-, integrin alpha11-
Gene:	Itga11  Location: Chr9:62585108-62691264 bp, + strand  Genetic Position: Chr9, 33.82 cM
Alliance:	Itga11tm1Dgul page

Germline Transmission:	Earliest citation of germline transmission: J:122349
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A construct containing IRES-lacZ-polyA-loxP-polyA-neo-pgk-loxP was inserted into exon 3. RT-PCR confirmed absence of transcript from exons 3 and beyond in mutants. The neo was subsequently removed by crossing with mice expressing cre recombinase in the germline. (J:122349)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itga11 Mutation:	75 strains or lines available

Original:	J:122349 Popova SN, et al., Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor. Mol Cell Biol. 2007 Jun;27(12):4306-16
All:	11 reference(s)