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Maml1tm1Mkit
Targeted Allele Detail
Summary
Symbol: Maml1tm1Mkit
Name: mastermind like transcriptional coactivator 1; targeted mutation 1, Motoo Kitagawa
MGI ID: MGI:3714162
Synonyms: Mam1-
Gene: Maml1  Location: Chr11:50146461-50183138 bp, - strand  Genetic Position: Chr11, 30.42 cM
Alliance: Maml1tm1Mkit page
Maml1tm1Mkit/Maml1tm1Mkit mice are growth retarded

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122286
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin resistance cassette. This exon contains the ATG and enncodes the basic domain of the protein. (J:122286)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Maml1 Mutation:  26 strains or lines available
References
Original:  J:122286 Oyama T, et al., Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9764-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory