Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Alkbh2tm1Klng
Name:	alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase; targeted mutation 1, Arne Klungland
MGI ID:	MGI:3714064
Synonyms:	mABH2 KO
Gene:	Alkbh2  Location: Chr5:114261987-114266279 bp, - strand  Genetic Position: Chr5, 55.97 cM
Alliance:	Alkbh2tm1Klng page

Germline Transmission:	Earliest citation of germline transmission: J:108782
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 3.2kb of sequence including all of exon 4. The deleted region contains the conserved 2-oxoglutarate- and Fe(II)-dependent oxygenase domain and the AlkB domain. (J:108782)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alkbh2 Mutation:	71 strains or lines available

Original:	J:108782 Ringvoll J, et al., Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO J. 2006 May 17;25(10):2189-98
All:	4 reference(s)