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Adamts5tm1.1Lex
Targeted Allele Detail
Summary
Symbol: Adamts5tm1.1Lex
Name: ADAM metallopeptidase with thrombospondin type 1 motif 5; targeted mutation 1.1, Lexicon Genetics
MGI ID: MGI:3710194
Synonyms: ADAMTS-5-deltacat, ADAMTS-5-delta-cat, ADAMTS5 delta-cat
Gene: Adamts5  Location: Chr16:85655045-85698013 bp, - strand  Genetic Position: Chr16, 48.34 cM
Alliance: Adamts5tm1.1Lex page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120892
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Exon 3 was removed via cre mediated recombination. (J:120892)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts5 Mutation:  54 strains or lines available
References
Original:  J:120892 East CJ, et al., ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan. J Biol Chem. 2007 Mar 23;282(12):8632-40
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory