Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Rasa3tm1Shiw Name: RAS p21 protein activator 3; targeted mutation 1, Shintaro Iwashita MGI ID: MGI:3710014 Synonyms: R-Ras gap- Gene: Rasa3  Location: Chr8:13617218-13727590 bp, - strand  Genetic Position: Chr8, 6.29 cM Alliance: Rasa3tm1Shiw page

Rasa3tm1Shiw/Rasa3tm1Shiw mice exhibit edema and hemorrhaging in the head and trunk Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:120930
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 11-12 were replaced with a neomycin resistance cassette. As expected, Northern blot and immunoblot analyses detected a transcript lacking 264 nucleotides corresponding to 88 amino acids without frameshift. (J:120930)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rasa3 Mutation:	62 strains or lines available

Original:	J:120930 Iwashita S, et al., Versatile roles of R-Ras GAP in neurite formation of PC12 cells and embryonic vascular development. J Biol Chem. 2007 Feb 9;282(6):3413-7
All:	2 reference(s)