Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sphk1tm1.1Cgh
Name:	sphingosine kinase 1; targeted mutation 1, Shaun R Coughlin
MGI ID:	MGI:3707992
Synonyms:	SphK1-
Gene:	Sphk1  Location: Chr11:116421751-116427501 bp, + strand  Genetic Position: Chr11, 81.42 cM, cytoband E2
Alliance:	Sphk1tm1.1Cgh page

Germline Transmission:	Earliest citation of germline transmission: J:120783
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A floxed neo cassette was inserted after exon 2 and a single loxP site was inserted after exon 6. In vivo Cre-mediated recombination then removed the neo cassette and exons 3 through 6 creating a null allele. (J:120783)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sphk1 Mutation:	30 strains or lines available

Original:	J:120783 Pappu R, et al., Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13;316(5822):295-8
All:	11 reference(s)