Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nxph3tm1.1Mami
Name:	neurexophilin 3; targeted mutation 1.1, Markus Missler
MGI ID:	MGI:3706428
Gene:	Nxph3  Location: Chr11:95400671-95405380 bp, - strand  Genetic Position: Chr11, 59.01 cM, cytoband C
Alliance:	Nxph3tm1.1Mami page

Germline Transmission:	Earliest citation of germline transmission: J:119861
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: In vivo cre mediated recombination removed all of exon 2. The absence of protein product was confirmed by western blot of tissue from homozygous mice, which showed antibody cross-reactivity to Nxph1, and from double homozygous mice lacking Nxph1 as well in which no protein band was detected. (J:119861)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nxph3 Mutation:	13 strains or lines available

Original:	J:119861 Beglopoulos V, et al., Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Mol Cell Biol. 2005 Aug;25(16):7278-88
All:	1 reference(s)