Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Dlg3tm1Grnt
Name:	discs large MAGUK scaffold protein 3; targeted mutation 1, Seth G N Grant
MGI ID:	MGI:3706312
Synonyms:	SAP102-
Gene:	Dlg3  Location: ChrX:99811328-99862016 bp, + strand  Genetic Position: ChrX, 43.72 cM, cytoband C2
Alliance:	Dlg3tm1Grnt page

Germline Transmission:	Earliest citation of germline transmission: J:120078
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2-8 were replaced with a neomycin resistance cassette flanked by loxP sites. Integration of the targeting vector caused a frame shift. Absence of protein was confirmed by Western blot and immunohistochemistry. (J:120078)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dlg3 Mutation:	28 strains or lines available

Original:	J:120078 Cuthbert PC, et al., Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies. J Neurosci. 2007 Mar 7;27(10):2673-82
All:	9 reference(s)