Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cybrd1tm1Nca
Name:	cytochrome b reductase 1; targeted mutation 1, Nancy C Andrews
MGI ID:	MGI:3702743
Synonyms:	Cybrd1-
Gene:	Cybrd1  Location: Chr2:70948398-70973270 bp, + strand  Genetic Position: Chr2, 42.38 cM, cytoband C3
Alliance:	Cybrd1tm1Nca page

Germline Transmission:	Earliest citation of germline transmission: J:119528
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting vector was designed to insert a loxP site into intron 1 and a loxP-flanked neo/cytosine deaminase cassette into intron 2. Transient expression of cre recombinase resulted in the removal of exon 2. Immunoblot confirmed absence of protein in mutant duodenal lysates. (J:119528)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cybrd1 Mutation:	18 strains or lines available

Original:	J:119528 Gunshin H, et al., Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood. 2005 Oct 15;106(8):2879-83
All:	1 reference(s)