Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcrbtm2Slek
Name:	T cell receptor beta chain; targeted mutation 2, Barry P Sleckman
MGI ID:	MGI:3702574
Synonyms:	Jbeta1M4
Gene:	Tcrb  Location: Chr6:40868230-41535305 bp, + strand  Genetic Position: Chr6, cytoband A-C

Germline Transmission:	Earliest citation of germline transmission: J:119552
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: ES cells containing Tcrbtm1Slek, which contain a loxP site in place of the Dbeta2-Jbeta2 gene cluster, were additionally targeted to replace the 5' Dbeta1 12-RSS with the Jbeta1.2 12-RSS. The allele also contains loxP and HindIII sites between Dbeta1 and Jbeta1.1, as well as the conversion of a bamHI site 3' of Jbeta1.2 to a PstI site. A floxed neo cassette was removed from the locus. (J:119552)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcrb Mutation:	94 strains or lines available

Original:	J:119552 Bassing CH, et al., Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 2000 Jun 1;405(6786):583-6
All:	4 reference(s)