Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Apobec2tm1Msn Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2; targeted mutation 1, Michael S Neuberger MGI ID: MGI:3701835 Gene: Apobec2  Location: Chr17:48726259-48739756 bp, - strand  Genetic Position: Chr17, 24.02 cM Alliance: Apobec2tm1Msn page

Myopathy in 8-10-month-old Apobec2tm1Msn/Apobec2tm1Msn mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:119326
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo cassette was inserted into exon 2 causing a null allele. A northern blot confirmed the ablation of expression and a western blot of heart and skeletal muscle contained no recognized protein (rabbit anti-APOBEC2 antiserum). (J:119326)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apobec2 Mutation:	17 strains or lines available

Original:	J:119326 Mikl MC, et al., Mice deficient in APOBEC2 and APOBEC3. Mol Cell Biol. 2005 Aug;25(16):7270-7
All:	3 reference(s)