Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hamptm1Svl
Name:	hepcidin antimicrobial peptide; targeted mutation 1, Sophie Vaulont
MGI ID:	MGI:3701082
Synonyms:	Hamp1-, Hepc1-
Gene:	Hamp  Location: Chr7:30641793-30643454 bp, - strand  Genetic Position: Chr7, 19.27 cM
Alliance:	Hamptm1Svl page

Germline Transmission:	Earliest citation of germline transmission: J:119004
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     The first two exons and part of exon 3 was replaced with a PGK-hygromycin cassette. (J:119004)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hamp Mutation:	11 strains or lines available

Original:	J:119004 Lesbordes-Brion JC, et al., Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood. 2006 Aug 15;108(4):1402-5
All:	38 reference(s)