Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ighmtm2.1Bgmn
Name:	immunoglobulin heavy constant mu; targeted mutation 2.1, Marianne Bruggemann
MGI ID:	MGI:3701077
Synonyms:	Cdelta
Gene:	Ighm  Location: Chr12:113382446-113386350 bp, - strand  Genetic Position: Chr12, 62.1 cM, cytoband F1-2
Alliance:	Ighmtm2.1Bgmn page

Germline Transmission:	Earliest citation of germline transmission: J:118453
Parent Cell Line:	ZX3 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutation:    Intragenic deletion   Mutation details: A puromycin resistance gene cassette with a 5' loxP site was inserted into exon 1 and 2 of the Igh Cmu gene segment, deleting 330bp of 3' of exon 1, intron 1 and 5' of exon 2. This insertion was done in ES cells that already had a neo cassette with a 3' loxP site in the alpha 3' enhancer of Igh Calpha (Rr151). Cre mediated recombination results in about a 200 kb deletion spanning the end of exon 1 to the alpha 3' enhancer. (J:118453)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ighm Mutation:	55 strains or lines available

Original:	J:118453 Ren L, et al., Silencing of the immunoglobulin heavy chain locus by removal of all eight constant-region genes in a 200-kb region. Genomics. 2004 Oct;84(4):686-95
All:	5 reference(s)