Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dlg4tm1Rlh
Name:	discs large MAGUK scaffold protein 4; targeted mutation 1, Richard L Huganir
MGI ID:	MGI:3700207
Synonyms:	Dlg4-
Gene:	Dlg4  Location: Chr11:69908029-69938107 bp, + strand  Genetic Position: Chr11, 42.96 cM, cytoband B4
Alliance:	Dlg4tm1Rlh page

Germline Transmission:	Earliest citation of germline transmission: J:118286
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons encoding PDZ 1 and 2 domains were replaced with a neomycin resistance cassette. This results in the production of an out of frame transcript. Western blot confirmed absence of protein in mutant mice. (J:118286)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dlg4 Mutation:	42 strains or lines available

Original:	J:118286 Beique JC, et al., Synapse-specific regulation of AMPA receptor function by PSD-95. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19535-40
All:	5 reference(s)