Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Flnatm1.2Caw
Name:	filamin, alpha; targeted mutation 1.2, Christopher A Walsh
MGI ID:	MGI:3699306
Synonyms:	FlnA-, FlnaK
Gene:	Flna  Location: ChrX:73267067-73293426 bp, - strand  Genetic Position: ChrX, 37.89 cM
Alliance:	Flnatm1.2Caw page

Germline Transmission:	Earliest citation of germline transmission: J:118252
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Crossing Flnatm1.1Caw females with males expressing a beta-actin cre transgene results in deletion of exons 3-7. Cre recombination in floxed ES cells to produce null mutants is inefficient because the cells are male-derived and deletion of the x-linked gene results in embryonic lethality. (J:118252)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flna Mutation:	18 strains or lines available

Original:	J:118252 Feng Y, et al., Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41
All:	6 reference(s)