Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dtltm1Hch
Name:	denticleless E3 ubiquitin protein ligase; targeted mutation 1, Hey-Chi Hsu
MGI ID:	MGI:3699089
Synonyms:	L2dtl-
Gene:	Dtl  Location: Chr1:191269468-191307656 bp, - strand  Genetic Position: Chr1, 96.44 cM, cytoband H6
Alliance:	Dtltm1Hch page

Germline Transmission:	Earliest citation of germline transmission: J:118159
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     The coding region of exon 1 was replaced by a floxed neomycin resistance cassette. (J:118159)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dtl Mutation:	47 strains or lines available

Original:	J:118159 Liu CL, et al., L2dtl is essential for cell survival and nuclear division in early mouse embryonic development. J Biol Chem. 2007 Jan 12;282(2):1109-18
All:	1 reference(s)