Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thbdtm2.1Emc
Name:	thrombomodulin; targeted mutation 2.1, Edward M Conway
MGI ID:	MGI:3698840
Synonyms:	TMLeD
Gene:	Thbd  Location: Chr2:148246391-148250108 bp, - strand  Genetic Position: Chr2, 73.45 cM
Alliance:	Thbdtm2.1Emc page

Germline Transmission:	Earliest citation of germline transmission: J:118000
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The floxed neo was removed from the locus, leaving a single loxP site as well as a locus lacking the NH2-terminal domain. (J:118000)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbd Mutation:	23 strains or lines available

Original:	J:118000 Conway EM, et al., The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med. 2002 Sep 2;196(5):565-77
All:	4 reference(s)