Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Prkntm1Ykt
Name:	parkin RBR E3 ubiquitin protein ligase; targeted mutation 1, Yasuko Kitao
MGI ID:	MGI:3698054
Gene:	Prkn  Location: Chr17:11059271-12282248 bp, + strand  Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
Alliance:	Prkntm1Ykt page

Germline Transmission:	Earliest citation of germline transmission: J:117737
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was replaced with a floxed pgk-neomycin cassette. Absence of protein was confirmed by Western blot analysis. (J:117737)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkn Mutation:	54 strains or lines available

Original:	J:117737 Kitao Y, et al., Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet. 2007 Jan 1;16(1):50-60
All:	5 reference(s)