Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hrctm1Blk
Name:	histidine rich calcium binding protein; targeted mutation 1, Brian L Black
MGI ID:	MGI:3697445
Gene:	Hrc  Location: Chr7:44984714-44988398 bp, + strand  Genetic Position: Chr7, 29.26 cM
Alliance:	Hrctm1Blk page

Germline Transmission:	Earliest citation of germline transmission: J:117648
Parent Cell Line:	KG-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 1. Lack of protein was confrmed by immunoblotting of mutant heart and skeletal muscle. (J:117648)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hrc Mutation:	43 strains or lines available

Original:	J:117648 Jaehnig EJ, et al., Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein. Mol Cell Biol. 2006 Dec;26(24):9315-26
All:	1 reference(s)