Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plce1tm1Avsm
Name:	phospholipase C, epsilon 1; targeted mutation 1, Alan V Smrcka
MGI ID:	MGI:3697316
Synonyms:	PLCepsilon-
Gene:	Plce1  Location: Chr19:38469557-38773474 bp, + strand  Genetic Position: Chr19, 33.16 cM
Alliance:	Plce1tm1Avsm page

Germline Transmission:	Earliest citation of germline transmission: J:117556
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 6 was replaced with a lacZ-neo gene so that both splice variants and the first functional domain would be deleted. Western blot confirmed absence of protein in mutant hearts. (J:117556)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plce1 Mutation:	110 strains or lines available

Original:	J:117556 Wang H, et al., Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circ Res. 2005 Dec 9;97(12):1305-13
All:	11 reference(s)