Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plagl1tm1Jour
Name:	pleiomorphic adenoma gene-like 1; targeted mutation 1, Laurent Journot
MGI ID:	MGI:3693683
Synonyms:	Zac1-
Gene:	Plagl1  Location: Chr10:12966576-13007438 bp, + strand  Genetic Position: Chr10, 4.72 cM
Alliance:	Plagl1tm1Jour page

Germline Transmission:	Earliest citation of germline transmission: J:116147
Parent Cell Line:	H1 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was desgned to replace sequence including the ATG and the entire zinc finger domain with a neomycin resistance cassette. Absence of protein in mutant pituitary glands was confirmed by Western blot analysis. (J:116147)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plagl1 Mutation:	32 strains or lines available

Original:	J:116147 Varrault A, et al., Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Dev Cell. 2006 Nov;11(5):711-22
All:	6 reference(s)