Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Crtaptm1Brle
Name:	cartilage associated protein; targeted mutation 1, Brendan Lee
MGI ID:	MGI:3693334
Synonyms:	Crtap-
Gene:	Crtap  Location: Chr9:114204204-114219743 bp, - strand  Genetic Position: Chr9, 64.39 cM, cytoband F3-F4
Alliance:	Crtaptm1Brle page

Germline Transmission:	Earliest citation of germline transmission: J:116096
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced part of exon 1 and all of exon 2. Absence of transcript was confirmed by Northern blot and RT-PCR analyses. (J:116096)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crtap Mutation:	20 strains or lines available

Original:	J:116096 Morello R, et al., CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta. Cell. 2006 Oct 20;127(2):291-304
All:	6 reference(s)