Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Kmt2ctm1.1Jwle Name: lysine (K)-specific methyltransferase 2C; targeted mutation 1.1, Jae Lee MGI ID: MGI:3693319 Synonyms: Mll3delta, Mll3tm1.1Rgr Gene: Kmt2c  Location: Chr5:25476796-25703781 bp, - strand  Genetic Position: Chr5, 12.35 cM Alliance: Kmt2ctm1.1Jwle page

Phenotypes of the Kmt2ctm1.1Jwle/Kmt2ctm1.1Jwle mouse Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:116064
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP site was inserted into intron 56 and an FRT site flanked neomycin resistance gene cassette followed by a second loxP site was inserted into intron 58. Sequence encoding 61 of the 121 amino acids of the SET domain were thus enclosed within loxP sites. Subsequent Cre-mediated recombination resulted in the loss of exons 57-58, including sequence encoding the RYINHS motif, which contributes to the catalytic core region of the SET domain. (J:116064)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmt2c Mutation:	179 strains or lines available

Original:	J:116064 Lee S, et al., Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15392-7
All:	7 reference(s)