Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Polhtm2Fmh
Name:	polymerase (DNA directed), eta (RAD 30 related); targeted mutation 2, Fumio Hanaoka
MGI ID:	MGI:3691063
Synonyms:	Polh-, Polh3Han, Polhtm3Han
Gene:	Polh  Location: Chr17:46482281-46513567 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband C
Alliance:	Polhtm2Fmh page

Germline Transmission:	Earliest citation of germline transmission: J:115000
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     A targeting vector was inserted into exon 8, resulting in the production of a truncated protein. (J:115000)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polh Mutation:	38 strains or lines available

Original:	J:115000 Ohkumo T, et al., UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota. Mol Cell Biol. 2006 Oct;26(20):7696-706
All:	6 reference(s)