Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adgrl1tm1Sud
Name:	adhesion G protein-coupled receptor L1; targeted mutation 1, Thomas C Sudhof
MGI ID:	MGI:3691022
Gene:	Adgrl1  Location: Chr8:84626734-84668583 bp, + strand  Genetic Position: Chr8, 40.22 cM
Alliance:	Adgrl1tm1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:115214
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2, which encodes amino acids 24-95, and some flanking intronic DNA have been replaced by a neomycin resistance cassette, generating a translational reading-frame shift. Immunoblot analysis with antibodies against the N-terminal, extracellular part of the protein demonstrated its absence in synoptosomes of homozygous mutant mice. (J:115214) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adgrl1 Mutation:	60 strains or lines available

Original:	J:115214 Tobaben S, et al., Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. J Biol Chem. 2002 Feb 22;277(8):6359-65
All:	1 reference(s)