Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sirt6tm1Fwa
Name:	sirtuin 6; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:3686893
Synonyms:	SIRT6KO
Gene:	Sirt6  Location: Chr10:81457621-81463631 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Sirt6tm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:112817
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A LacZ gene was inserted in frame after the first 21 bp of exon 1 via homologous recombination replacing exons 1 to 6. (J:112817)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sirt6 Mutation:	39 strains or lines available

Original:	J:112817 Mostoslavsky R, et al., Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006 Jan 27;124(2):315-29
All:	27 reference(s)