Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arhgef1tm1.1Rmt
Name:	Rho guanine nucleotide exchange factor 1; targeted mutation 1.1, Raul M Torres
MGI ID:	MGI:3686863
Synonyms:	Lsc-
Gene:	Arhgef1  Location: Chr7:24602337-24626019 bp, + strand  Genetic Position: Chr7, 13.52 cM
Alliance:	Arhgef1tm1.1Rmt page

Germline Transmission:	Earliest citation of germline transmission: J:113295
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Approximately 4.9 of sequence including the putative regulatory region and first exon was deleted via cre-mediated recombination. Transcript and protein were demonstrated to be absent by Northern and Western blot analyses, respectively. (J:113295)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef1 Mutation:	73 strains or lines available

Original:	J:113295 Rubtsov A, et al., Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity. 2005 Nov;23(5):527-38
All:	7 reference(s)