Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grm3tm1Ddsc
Name:	glutamate receptor, metabotropic 3; targeted mutation 1, Darryle D Schoepp
MGI ID:	MGI:3665324
Synonyms:	mGlu3-, mGluR3-KO
Gene:	Grm3  Location: Chr5:9535541-9775170 bp, - strand  Genetic Position: Chr5, 3.69 cM
Alliance:	Grm3tm1Ddsc page

Germline Transmission:	Earliest citation of germline transmission: J:113260
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced most of the third exon that encodes for a large portion of the ligand-binding domain. (J:113260)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grm3 Mutation:	54 strains or lines available

Original:	J:113260 Linden AM, et al., Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. Psychopharmacology (Berl). 2005 Apr;179(1):284-91
All:	9 reference(s)