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Seletm1Dmil
Targeted Allele Detail
Summary
Symbol: Seletm1Dmil
Name: selectin, endothelial cell; targeted mutation 1, David Milstone
MGI ID: MGI:3665314
Synonyms: E-, E-selectin-
Gene: Sele  Location: Chr1:163875773-163885246 bp, + strand  Genetic Position: Chr1, 71.35 cM
Alliance: Seletm1Dmil page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113169
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe neomycin resistance gene was substituted in reverse transcriptional orientation for sequence spanning from exon 1 to exon 3. Northern blot confirmed absence of transcript in mutant kidney, lung and heart samples. (J:113169)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Sele Mutation:  51 strains or lines available
References
Original:  J:113169 Milstone DS, et al., Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium. Microcirculation. 1998;5(2-3):153-71
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory