Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rock1tm1Liao
Name:	Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, James K Liao
MGI ID:	MGI:3665285
Synonyms:	Rock1-, Rock I-
Gene:	Rock1  Location: Chr18:10064401-10182045 bp, - strand  Genetic Position: Chr18, 4.91 cM, cytoband A2
Alliance:	Rock1tm1Liao page

Germline Transmission:	Earliest citation of germline transmission: J:112242
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 1b was removed via cre-mediated recombination, resulting in a frame shift that created a stop codon in exon 1c, preventing translation of the functional protein. (J:112242)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rock1 Mutation:	57 strains or lines available

Original:	J:112242 Rikitake Y, et al., Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation. 2005 Jun 21;111(24):3261-8
All:	13 reference(s)