Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mr1tm1Gfn
Name:	major histocompatibility complex, class I-related; targeted mutation 1, Susan Gilfillan
MGI ID:	MGI:3664578
Synonyms:	Mr1-
Gene:	Mr1  Location: Chr1:155003620-155022560 bp, - strand  Genetic Position: Chr1, 66.45 cM, cytoband H1
Alliance:	Mr1tm1Gfn page

Germline Transmission:	Earliest citation of germline transmission: J:113083
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A vector was designed to delete a 1.4 kb region containing exons 2 and 3, which encode the alpha1 and alpha2 domains of the protein. Northern blot failed to detect transcript in mutant livers. (J:113083)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

104036 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mr1 Mutation:	26 strains or lines available

Original:	J:113083 Treiner E, et al., Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature. 2003 Mar 13;422(6928):164-9
All:	37 reference(s)