Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Tnip2tm1.1Sley
Name:	TNFAIP3 interacting protein 2; targeted mutation 1.1, Steven C Ley
MGI ID:	MGI:3664444
Synonyms:	Tnip2-, Tnip2delta
Gene:	Tnip2  Location: Chr5:34653440-34671323 bp, - strand  Genetic Position: Chr5, 17.89 cM
Alliance:	Tnip2tm1.1Sley page

Germline Transmission:	Earliest citation of germline transmission: J:112395
Parent Cell Line:	PC3 (ES Cell)
Strain of Origin:	129S4/SvJae-Tg(Prm-cre)70Og

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of a targeting vector into PC3 ES cells placed a loxP site in intron 2 and a floxed neo resistance cassette in intron 5. Cre-mediated excision removed exons 3-5 upon transmission from male chimeras. Immunoblot confirmed absence of protein in mutant mice. (J:112395)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnip2 Mutation:	21 strains or lines available

Original:	J:112395 Papoutsopoulou S, et al., ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nat Immunol. 2006 Jun;7(6):606-15
All:	3 reference(s)