Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ncoa1tm1.1Hkaw
Name:	nuclear receptor coactivator 1; targeted mutation 1.1, Hiroshi Kawaguchi
MGI ID:	MGI:3664107
Synonyms:	SRC-1-
Gene:	Ncoa1  Location: Chr12:4297362-4527182 bp, - strand  Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
Alliance:	Ncoa1tm1.1Hkaw page

Germline Transmission:	Earliest citation of germline transmission: J:111490
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Cre-mediated deletion of exon 4 resulted in the creation of a stop codon at exon 5 by splicing exon 3 and 5 transcripts. The truncated protein resulting from this allele lacks the C-terminal region. (J:111490)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa1 Mutation:	169 strains or lines available

Original:	J:111490 Yamada T, et al., SRC-1 is necessary for skeletal responses to sex hormones in both males and females. J Bone Miner Res. 2004 Sep;19(9):1452-61
All:	1 reference(s)