Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrp5tm1Lex
Name:	low density lipoprotein receptor-related protein 5; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:3663738
Synonyms:	Lrp5-, Lrp5deltaexon1
Gene:	Lrp5  Location: Chr19:3634828-3736564 bp, - strand  Genetic Position: Chr19, 3.33 cM, cytoband B
Alliance:	Lrp5tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:111359
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A targeting vector was designed to inactivate the locus by inserting an IRES-betagal-MC1-neo into exon 1. Expression of the betagal would have been under the control of the endogenous promoter, however, no expression was detected. RT-PCR failed to detect wild-type transcripts resulting from exon 1. Protein analysis failed to detect immunoreactivity in mutants. (J:111359)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp5 Mutation:	81 strains or lines available

Original:	J:111359 Holmen SL, et al., Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res. 2004 Dec;19(12):2033-40
All:	10 reference(s)