Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Kndc1tm1Mnkm Name: kinase non-catalytic C-lobe domain (KIND) containing 1; targeted mutation 1, Manabu Nakayama MGI ID: MGI:3663685 Synonyms: KIAA1768- Gene: Kndc1  Location: Chr7:139474612-139521450 bp, + strand  Genetic Position: Chr7, 84.89 cM Alliance: Kndc1tm1Mnkm page

Increased branches and terminals of cerebellar granule cell dendrites in Kndc1tm1Mnkm/Kndc1tm1Mnkm cerebella Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:111319
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A sequence of 700 bp, including part of exons 4 and 5, was replaced with a neo cassette. Northern blot analysis of RNA purified from adult brains failed to detect intact mRNA transcript in homozygous mutant mice. (J:111319)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kndc1 Mutation:	93 strains or lines available

Original:	J:111319 Nakayama M, et al., A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. FASEB J. 2006 Aug;20(10):1718-20
All:	2 reference(s)