Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Scnn1gtm1Bhk
Name:	sodium channel, nonvoltage-gated 1 gamma; targeted mutation 1, Beverly H Koller
MGI ID:	MGI:3663382
Synonyms:	gammaENaC-
Gene:	Scnn1g  Location: Chr7:121333702-121367698 bp, + strand  Genetic Position: Chr7, 65.07 cM
Alliance:	Scnn1gtm1Bhk page

Germline Transmission:	Earliest citation of germline transmission: J:50528
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced the exon with the putative start codon. Northern blot analysis on RNA derived from kidney demonstrated that no detectable protein is expressed from this allele. (J:50528)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scnn1g Mutation:	33 strains or lines available

Original:	J:50528 Barker PM, et al., Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism. J Clin Invest. 1998 Oct 15;102(8):1634-40
All:	2 reference(s)