Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igfbp3tm1Jep
Name:	insulin-like growth factor binding protein 3; targeted mutation 1, John E Pintar
MGI ID:	MGI:3663361
Synonyms:	BP3KO
Gene:	Igfbp3  Location: Chr11:7156086-7163923 bp, - strand  Genetic Position: Chr11, 4.75 cM
Alliance:	Igfbp3tm1Jep page

Germline Transmission:	Earliest citation of germline transmission: J:112029
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 1, including the translation start site and signal peptide, was replaced by a neomycin resistance cassette. Western blot failed to detect protein in mutants. (J:112029)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igfbp3 Mutation:	21 strains or lines available

Original:	J:112029 Ning Y, et al., Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Mol Endocrinol. 2006 Sep;20(9):2173-86
All:	14 reference(s)