Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mrtfatm1Eno
Name:	myocardin related transcription factor A; targeted mutation 1, Eric N Olson
MGI ID:	MGI:3662669
Synonyms:	MRTFA-
Gene:	Mrtfa  Location: Chr15:80896482-81074937 bp, - strand  Genetic Position: Chr15, 37.98 cM
Alliance:	Mrtfatm1Eno page

Germline Transmission:	Earliest citation of germline transmission: J:111412
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A vector was designed to delete a part of exon 9 and all of exon 10, which encode the basic, glutamine-rich and SAP domains. A lacZ was fused in frame with exon 9 and a neo cassette. RT-PCR demonstrated that the correct exons were deleted and that exon 8 was spliced to exon 12, thereby deleting the lacZ-neo cassette. The resulting truncated protein would be nonfunctional. (J:111412)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mrtfa Mutation:	32 strains or lines available

Original:	J:111412 Li S, et al., Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells. Mol Cell Biol. 2006 Aug;26(15):5797-808
All:	23 reference(s)